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Genome Organization And Function In The Cell Nucleus - Karsten Rippe
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(*)
Karsten Rippe:

Genome Organization And Function In The Cell Nucleus - libro nuevo

ISBN: 9783527640010

ID: 9783527640010

InhaltsangabePreface xixList of Contributors xxi1 Deciphering DNA Sequence Information 1Mark Kaganovich and Michael Snyder1.1 Introduction 11.2 Genes and Transcribed Regions 11.3 Non-Coding Genomic Elements 41.4 Regulatory Information 101.5 Individual Genetic Polymorphisms and Their Effect on Gene Expression 161.6 Conclusion 162 DNA Methylation 21Carina Frauer, Fabio Spada, and Heinrich Leonhardt2.1 Introduction 212.2 Eukaryotic DNA Methyltransferases 242.3 Distribution of 5-Methylcytosine in the Mammalian Genome 272.4 Control of Gene Expression by DNA Methylation 312.5 DNA Demethylation 373 Nucleosomes as Control Elements for Accessing the Genome 55Mekonnen Lemma Dechassa and Karolin Luger3.1 Introduction and Basic Terminology 553.2 Nucleosomes are the Building Blocks of Chromatin 563.3 Nucleosomes Are Dynamic Macromolecular Assemblies 633.4 Histone Variants and Their Effect on Nucleosome Structure and Dynamics 663.5 Histone Modifications in Nucleosome and Chromatin Structure 683.6 DNA Sequence and Nucleosome Positioning 703.7 Histone Chaperones and Chromatin Dynamics 733.8 Outlook and Concluding Remarks 754 Histone Modifications and Their Role as Epigenetic Marks 89Karl Nightingale4.1 The Complexity of Histone Modifications 894.2 Regulating Histone Modifications in Chromatin 934.3 The & #8220 Histone Code& #8221 Hypothesis 954.4 Exploiting the Complexity of the Histone Code: & #8220 Crosstalk& #8221 Between Different Modifications 984.5 Are Histone Modifications Heritable Epigenetic Marks 1044.6 Conclusions 1065 Chromatin Remodeling and Nucleosome Positioning 111Gernot La& #168 ngst, Vladimir B. Teif, and Karsten Rippe5.1 Introduction 1115.2 Chromatin Remodeling Complexes 1125.3 Mechanisms of Nucleosome Translocations 1155.4 Positioning Nucleosomes in the Genome 1185.5 Gene Regulation via Nucleosome Positioning 1245.6 Conclusions 1276 The Folding of the Nucleosome Chain 139Karsten Rippe6.1 Introduction 1396.2 Experimental Systems 1406.3 Nucleosome& #8211 Nucleosome Interactions 1426.4 DNA Interactions with the Histone Octamer Protein Core 1456.5 Architectural Chromosomal Proteins and Chromatin States 1476.6 Chromatin Fiber Conformations 1506.7 Conclusions 1547 The Crowded Environment of the Genome 169Ron Hancock7.1 Introduction 1697.2 Basics 1697.3 Physicochemical Parameters of the Genome& #8217 s Environment 1717.4 Implications of a Crowded Environment for the Conformation of the Interphase Genome 1717.5 Assembly and Localization of Macromolecular Machines for Genome Transcription and Replication 1757.6 The Environment of the Genome during Mitosis 1777.7 Effects of a Crowded Environment on Searching for Targets in the Genome 1787.8 The Relative Importance of Entropic and Ionic Interactions for the Conformations and Interactions of Macromolecules in the Nucleus 1797.9 The Evolution of Genomes 1808 The Nuclear Lamina as a Chromatin Organizer 185Nikolaj Zuleger and Eric C. Schirmer8.1 Introduction 1858.2 Genome Organization with Respect to the Nuclear Periphery 1878.3 Interactions between NE Proteins and Chromatin Proteins/Chromatin Regulatory Proteins 1908.4 Mechanisms Directin and Quality Control 255Ute Schmidt and Edouard Bertrand11.1 Introduction 25511.2 Biosynthesis of Messenger RNA 25511.3 Nuclear Quality Control 26511.4 Cytoplasmic Messenger RNA Quality Control: Nonsense-Mediated Decay, No-Go and Non-Stop Decay 26811.5 Concluding Remarks 27312 The Nucleolus 279Saskia Hutten, Belinda J. Westman, Franc-ois-Michel Boisvert, Silvana van Koningsbruggen, and Angus I. Lamond12.1 Introduction 27912.2 The Nucleolus and Its DNA 28012.3 The Nucleolus and RNPs: Temporary Visitors or Permanent Residents 28512.4 The Nucleolar Proteome 29212.5 Concluding Remarks 29513 Non-Coding RNAs as Regulators of Transcription and Genome Organization 309Katalin Fejes To& #180 th and Gregory Hannon13.1 Introduction 30913.2 Classification of Non-Coding RNAs 31113.3 Small Regulatory RNAs and Their Diverse Nuclear Functions 31413.4 ncRNAs in Dosage Compensation 32413.5 Developmental Regulation of Hox Clusters by Cis- and Trans-Acting ncRNAs 32813.6 Mechanisms of Transcriptional Regulation by Long ncRNAs 33013.7 Conclusions 33814 RNA Networks as Digital Control Circuits of Nuclear Functions 353John S. Mattick14.1 Introduction 35314.2 The Information Content of the Genome 35314.3 The Hidden Layer of Developmentally Expressed Non-Coding RNAs 35414.4 RNA Control of Nuclear Functions 35514.5 RNA as the Adaptor in Digital& #8211 Analog Transactions 35614.6 RNA as the Substrate for Environment& #8211 Epigenome Interactions 35714.7 Conclusion 35815 DNA Replication and Inheritance of Epigenetic States 365Armelle Corpet and Genevie`ve Almouzni15.1 Replication in a Chromatin Context: Basic Issues and Principles 36515.2 Duplication of Nucleosome Organization 36815.3 Maintenance of Epigenetic Marks and Post-translational Modifications 37515.4 Concluding Remarks 38316 Interplay and Quality Control of DNA Damage Repair Mechanisms 395Berina Eppink, Jeroen Essers and Roland Kanaar16.1 Introduction 39516.2 DNA Repair Pathways 39616.3 Repairing DSBs 40016.4 Repair during Replication 40416.5 Interplay and Quality Control during DNA Damage Repair 40916.6 Applications of Mechanistic Insight in DNA Repair in Anti-Cancer Treatment 41017 Higher Order Chromatin Organization and Dynamics 417Hilmar Strickfaden, Thomas Cremer, and Karsten Rippe17.1 Introduction 41717.2 Higher Order Chromatin Organization: From 10-nm Thick Nucleosome Chains to Chromosome Territories 41817.3 Genome Accessibility 42417.4 Mobility of Chromosomal Loci and Nuclear Bodies 42617.5 Mitosis Causes Drastic Changes of Chromosome Territory Proximity Patterns in Cycling Cells 42917.6 Large-Scale Chromatin Dynamics in Nuclei of Cycling and Post-Mitotic Cells 43117.7 Considerations on Possible Mechanisms of Large-Scale Chromatin Dynamics 43418 The Mitotic Chromosome: Structure and Mechanics 449John F. Marko18.1 Introduction 44918.2 Structural Components of Mitotic Chromosomes 45018.3 Large-Scale Organization of Mitotic Chromosomes 45718.4 Mechanics of Mitotic Chromosomes 45918.5 Molecular Connectivity of Mitotic Chromosomes 46518.6 A Model for Mitotic Chromosome Structure and Function 46818.7 Open Questions 47419 Meiotic Chromosome Dynamics 487Nancy Kleckner, Liangran Zha Genome Organization And Function In The Cell Nucleus: InhaltsangabePreface xixList of Contributors xxi1 Deciphering DNA Sequence Information 1Mark Kaganovich and Michael Snyder1.1 Introduction 11.2 Genes and Transcribed Regions 11.3 Non-Coding Genomic Elements 41.4 Regulatory Information 101.5 Individual Genetic Polymorphisms and Their Effect on Gene Expression 161.6 Conclusion 162 DNA Methylation 21Carina Frauer, Fabio Spada, and Heinrich Leonhardt2.1 Introduction 212.2 Eukaryotic DNA Methyltransferases 242.3 Distribution of 5-Methylcytosine in the Mammalian Genome 272.4 Control of Gene Expression by DNA Methylation 312.5 DNA Demethylation 373 Nucleosomes as Control Elements for Accessing the Genome 55Mekonnen Lemma Dechassa and Karolin Luger3.1 Introduction and Basic Terminology 553.2 Nucleosomes are the Building Blocks of Chromatin 563.3 Nucleosomes Are Dynamic Macromolecular Assemblies 633.4 Histone Variants and Their Effect on Nucleosome Structure and Dynamics 663.5 Histone Modifications in Nucleosome and Chromatin Structure 683.6 DNA Sequence and Nucleosome Positioning 703.7 Histone Chaperones and Chromatin Dynamics 733.8 Outlook and Concluding Remarks 754 Histone Modifications and Their Role as Epigenetic Marks 89Karl Nightingale4.1 The Complexity of Histone Modifications 894.2 Regulating Histone Modifications in Chromatin 934.3 The & #8220 Histone Code& #8221 Hypothesis 954.4 Exploiting the Complexity of the Histone Code: & #8220 Crosstalk& #8221 Between Different Modifications 984.5 Are Histone Modifications Heritable Epigenetic Marks 1044.6 Conclusions 1065 Chromatin Remodeling and Nucleosome Positioning 111Gernot La& #168 ngst, Vladimir B. Teif, and Karsten Rippe5.1 Introduction 1115.2 Chromatin Remodeling Complexes 1125.3 Mechanisms of Nucleosome Translocations 1155.4 Positioning Nucleosomes in the Genome 1185.5 Gene Regulation via Nucleosome Positioning 1245.6 Conclusions 1276 The Folding of the Nucleosome Chain 139Karsten Rippe6.1 Introduction 1396.2 Experimental Systems 1406.3 Nucleosome& #8211 Nucleosome Interactions 1426.4 DNA Interactions with the Histone Octamer Protein Core 1456.5 Architectural Chromosomal Proteins and Chromatin States 1476.6 Chromatin Fiber Conformations 1506.7 Conclusions 1547 The Crowded Environment of the Genome 169Ron Hancock7.1 Introduction 1697.2 Basics 1697.3 Physicochemical Parameters of the Genome& #8217 s Environment 1717.4 Implications of a Crowded Environment for the Conformation of the Interphase Genome 1717.5 Assembly and Localization of Macromolecular Machines for Genome Transcription and Replication 1757.6 The Environment of the Genome during Mitosis 1777.7 Effects of a Crowded Environment on Searching for Targets in the Genome 1787.8 The Relative Importance of Entropic and Ionic Interactions for the Conformations and Interactions of Macromolecules in the Nucleus 1797.9 The Evolution of Genomes 1808 The Nuclear Lamina as a Chromatin Organizer 185Nikolaj Zuleger and Eric C. Schirmer8.1 Introduction 1858.2 Genome Organization with Respect to the Nuclear Periphery 1878.3 Interactions between NE Proteins and Chromatin Proteins/Chromatin Regulatory Proteins 1908.4 Mechanisms Directin and Quality Control 255Ute Schmidt and Edouard Bertrand11.1 Introduction 25511.2 Biosynthesis of Messenger RNA 25511.3 Nuclear Quality Control 26511.4 Cytoplasmic Messenger RNA Quality Control: Nonsense-Mediated Decay, No-Go and Non-Stop Decay 26811.5 Concluding Remarks 27312 The Nucleolus 279Saskia Hutten, Belinda J. Westman, Franc-ois-Michel Boisvert, Silvana van Koningsbruggen, and Angus I. Lamond12.1 Introduction 27912.2 The Nucleolus and Its DNA 28012.3 The Nucleolus and RNPs: Temporary Visitors or Permanent Residents 28512.4 The Nucleolar Proteome 29212.5 Concluding Remarks 29513 Non-Coding RNAs as Regulators of Transcription and Genome Organization 309Katalin Fejes To& #180 th and Gregory Hannon13.1 Introduction 30913.2 Classification of Non-Coding RNAs 31113.3 Small Regulatory RNAs and Their Diverse Nuclear Functions 31413.4 ncRNAs in Dosage Compensation 32413.5 Developmental Regulation of Hox Clusters by Cis- and Trans-Acting ncRNAs 32813.6 Mechanisms of Transcriptional Regulation by Long ncRNAs 33013.7 Conclusions 33814 RNA Networks as Digital Control Circuits of Nuclear Functions 353John S. Mattick14.1 Introduction 35314.2 The Information Content of the Genome 35314.3 The Hidden Layer of Developmentally Expressed Non-Coding RNAs 35414.4 RNA Control of Nuclear Functions 35514.5 RNA as the Adaptor in Digital& #8211 Analog Transactions 35614.6 RNA as the Substrate for Environment& #8211 Epigenome Interactions 35714.7 Conclusion 35815 DNA Replication and Inheritance of Epigenetic States 365Armelle Corpet and Genevie`ve Almouzni15.1 Replication in a Chromatin Context: Basic Issues and Principles 36515.2 Duplication of Nucleosome Organization 36815.3 Maintenance of Epigenetic Marks and Post-translational Modifications 37515.4 Concluding Remarks 38316 Interplay and Quality Control of DNA Damage Repair Mechanisms 395Berina Eppink, Jeroen Essers and Roland Kanaar16.1 Introduction 39516.2 DNA Repair Pathways 39616.3 Repairing DSBs 40016.4 Repair during Replication 40416.5 Interplay and Quality Control during DNA Damage Repair 40916.6 Applications of Mechanistic Insight in DNA Repair in Anti-Cancer Treatment 41017 Higher Order Chromatin Organization and Dynamics 417Hilmar Strickfaden, Thomas Cremer, and Karsten Rippe17.1 Introduction 41717.2 Higher Order Chromatin Organization: From 10-nm Thick Nucleosome Chains to Chromosome Territories 41817.3 Genome Accessibility 42417.4 Mobility of Chromosomal Loci and Nuclear Bodies 42617.5 Mitosis Causes Drastic Changes of Chromosome Territory Proximity Patterns in Cycling Cells 42917.6 Large-Scale Chromatin Dynamics in Nuclei of Cycling and Post-Mitotic Cells 43117.7 Considerations on Possible Mechanisms of Large-Scale Chromatin Dynamics 43418 The Mitotic Chromosome: Structure and Mechanics 449John F. Marko18.1 Introduction 44918.2 Structural Components of Mitotic Chromosomes 45018.3 Large-Scale Organization of Mitotic Chromosomes 45718.4 Mechanics of Mitotic Chromosomes 45918.5 Molecular Connectivity of Mitotic Chromosomes 46518.6 A Model for Mitotic Chromosome Structure and Function 46818.7 Open Questions 47419 Meiotic Chromosome Dynamics 487Nancy Kleckner, Liangran Zha Biochemie u. Chemische Biologie Biochemistry (Chemical Biology) Biophysics Biophysik Biowissenschaften Cell Biology Chemie Chemische Biologie Chemistry Genetik Genom Life Sciences Molecular Genetics Molekulargenetik Physics Physik Zellbiol, Wiley-VCH

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Genome Organization And Function In The Cell Nucleus - Karsten Rippe
Libro agotado
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Karsten Rippe:

Genome Organization And Function In The Cell Nucleus - libro nuevo

ISBN: 9783527640010

ID: 9783527640010

InhaltsangabePreface xixList of Contributors xxi1 Deciphering DNA Sequence Information 1Mark Kaganovich and Michael Snyder1.1 Introduction 11.2 Genes and Transcribed Regions 11.3 Non-Coding Genomic Elements 41.4 Regulatory Information 101.5 Individual Genetic Polymorphisms and Their Effect on Gene Expression 161.6 Conclusion 162 DNA Methylation 21Carina Frauer, Fabio Spada, and Heinrich Leonhardt2.1 Introduction 212.2 Eukaryotic DNA Methyltransferases 242.3 Distribution of 5-Methylcytosine in the Mammalian Genome 272.4 Control of Gene Expression by DNA Methylation 312.5 DNA Demethylation 373 Nucleosomes as Control Elements for Accessing the Genome 55Mekonnen Lemma Dechassa and Karolin Luger3.1 Introduction and Basic Terminology 553.2 Nucleosomes are the Building Blocks of Chromatin 563.3 Nucleosomes Are Dynamic Macromolecular Assemblies 633.4 Histone Variants and Their Effect on Nucleosome Structure and Dynamics 663.5 Histone Modifications in Nucleosome and Chromatin Structure 683.6 DNA Sequence and Nucleosome Positioning 703.7 Histone Chaperones and Chromatin Dynamics 733.8 Outlook and Concluding Remarks 754 Histone Modifications and Their Role as Epigenetic Marks 89Karl Nightingale4.1 The Complexity of Histone Modifications 894.2 Regulating Histone Modifications in Chromatin 934.3 The & #8220 Histone Code& #8221 Hypothesis 954.4 Exploiting the Complexity of the Histone Code: & #8220 Crosstalk& #8221 Between Different Modifications 984.5 Are Histone Modifications Heritable Epigenetic Marks 1044.6 Conclusions 1065 Chromatin Remodeling and Nucleosome Positioning 111Gernot La& #168 ngst, Vladimir B. Teif, and Karsten Rippe5.1 Introduction 1115.2 Chromatin Remodeling Complexes 1125.3 Mechanisms of Nucleosome Translocations 1155.4 Positioning Nucleosomes in the Genome 1185.5 Gene Regulation via Nucleosome Positioning 1245.6 Conclusions 1276 The Folding of the Nucleosome Chain 139Karsten Rippe6.1 Introduction 1396.2 Experimental Systems 1406.3 Nucleosome& #8211 Nucleosome Interactions 1426.4 DNA Interactions with the Histone Octamer Protein Core 1456.5 Architectural Chromosomal Proteins and Chromatin States 1476.6 Chromatin Fiber Conformations 1506.7 Conclusions 1547 The Crowded Environment of the Genome 169Ron Hancock7.1 Introduction 1697.2 Basics 1697.3 Physicochemical Parameters of the Genome& #8217 s Environment 1717.4 Implications of a Crowded Environment for the Conformation of the Interphase Genome 1717.5 Assembly and Localization of Macromolecular Machines for Genome Transcription and Replication 1757.6 The Environment of the Genome during Mitosis 1777.7 Effects of a Crowded Environment on Searching for Targets in the Genome 1787.8 The Relative Importance of Entropic and Ionic Interactions for the Conformations and Interactions of Macromolecules in the Nucleus 1797.9 The Evolution of Genomes 1808 The Nuclear Lamina as a Chromatin Organizer 185Nikolaj Zuleger and Eric C. Schirmer8.1 Introduction 1858.2 Genome Organization with Respect to the Nuclear Periphery 1878.3 Interactions between NE Proteins and Chromatin Proteins/Chromatin Regulatory Proteins 1908.4 Mechanisms Directin and Quality Control 255Ute Schmidt and Edouard Bertrand11.1 Introduction 25511.2 Biosynthesis of Messenger RNA 25511.3 Nuclear Quality Control 26511.4 Cytoplasmic Messenger RNA Quality Control: Nonsense-Mediated Decay, No-Go and Non-Stop Decay 26811.5 Concluding Remarks 27312 The Nucleolus 279Saskia Hutten, Belinda J. Westman, Franc-ois-Michel Boisvert, Silvana van Koningsbruggen, and Angus I. Lamond12.1 Introduction 27912.2 The Nucleolus and Its DNA 28012.3 The Nucleolus and RNPs: Temporary Visitors or Permanent Residents 28512.4 The Nucleolar Proteome 29212.5 Concluding Remarks 29513 Non-Coding RNAs as Regulators of Transcription and Genome Organization 309Katalin Fejes To& #180 th and Gregory Hannon13.1 Introduction 30913.2 Classification of Non-Coding RNAs 31113.3 Small Regulatory RNAs and Their Diverse Nuclear Functions 31413.4 ncRNAs in Dosage Compensation 32413.5 Developmental Regulation of Hox Clusters by Cis- and Trans-Acting ncRNAs 32813.6 Mechanisms of Transcriptional Regulation by Long ncRNAs 33013.7 Conclusions 33814 RNA Networks as Digital Control Circuits of Nuclear Functions 353John S. Mattick14.1 Introduction 35314.2 The Information Content of the Genome 35314.3 The Hidden Layer of Developmentally Expressed Non-Coding RNAs 35414.4 RNA Control of Nuclear Functions 35514.5 RNA as the Adaptor in Digital& #8211 Analog Transactions 35614.6 RNA as the Substrate for Environment& #8211 Epigenome Interactions 35714.7 Conclusion 35815 DNA Replication and Inheritance of Epigenetic States 365Armelle Corpet and Genevie`ve Almouzni15.1 Replication in a Chromatin Context: Basic Issues and Principles 36515.2 Duplication of Nucleosome Organization 36815.3 Maintenance of Epigenetic Marks and Post-translational Modifications 37515.4 Concluding Remarks 38316 Interplay and Quality Control of DNA Damage Repair Mechanisms 395Berina Eppink, Jeroen Essers and Roland Kanaar16.1 Introduction 39516.2 DNA Repair Pathways 39616.3 Repairing DSBs 40016.4 Repair during Replication 40416.5 Interplay and Quality Control during DNA Damage Repair 40916.6 Applications of Mechanistic Insight in DNA Repair in Anti-Cancer Treatment 41017 Higher Order Chromatin Organization and Dynamics 417Hilmar Strickfaden, Thomas Cremer, and Karsten Rippe17.1 Introduction 41717.2 Higher Order Chromatin Organization: From 10-nm Thick Nucleosome Chains to Chromosome Territories 41817.3 Genome Accessibility 42417.4 Mobility of Chromosomal Loci and Nuclear Bodies 42617.5 Mitosis Causes Drastic Changes of Chromosome Territory Proximity Patterns in Cycling Cells 42917.6 Large-Scale Chromatin Dynamics in Nuclei of Cycling and Post-Mitotic Cells 43117.7 Considerations on Possible Mechanisms of Large-Scale Chromatin Dynamics 43418 The Mitotic Chromosome: Structure and Mechanics 449John F. Marko18.1 Introduction 44918.2 Structural Components of Mitotic Chromosomes 45018.3 Large-Scale Organization of Mitotic Chromosomes 45718.4 Mechanics of Mitotic Chromosomes 45918.5 Molecular Connectivity of Mitotic Chromosomes 46518.6 A Model for Mitotic Chromosome Structure and Function 46818.7 Open Questions 47419 Meiotic Chromosome Dynamics 487Nancy Kleckner, Liangran Zha Genome Organization And Function In The Cell Nucleus: InhaltsangabePreface xixList of Contributors xxi1 Deciphering DNA Sequence Information 1Mark Kaganovich and Michael Snyder1.1 Introduction 11.2 Genes and Transcribed Regions 11.3 Non-Coding Genomic Elements 41.4 Regulatory Information 101.5 Individual Genetic Polymorphisms and Their Effect on Gene Expression 161.6 Conclusion 162 DNA Methylation 21Carina Frauer, Fabio Spada, and Heinrich Leonhardt2.1 Introduction 212.2 Eukaryotic DNA Methyltransferases 242.3 Distribution of 5-Methylcytosine in the Mammalian Genome 272.4 Control of Gene Expression by DNA Methylation 312.5 DNA Demethylation 373 Nucleosomes as Control Elements for Accessing the Genome 55Mekonnen Lemma Dechassa and Karolin Luger3.1 Introduction and Basic Terminology 553.2 Nucleosomes are the Building Blocks of Chromatin 563.3 Nucleosomes Are Dynamic Macromolecular Assemblies 633.4 Histone Variants and Their Effect on Nucleosome Structure and Dynamics 663.5 Histone Modifications in Nucleosome and Chromatin Structure 683.6 DNA Sequence and Nucleosome Positioning 703.7 Histone Chaperones and Chromatin Dynamics 733.8 Outlook and Concluding Remarks 754 Histone Modifications and Their Role as Epigenetic Marks 89Karl Nightingale4.1 The Complexity of Histone Modifications 894.2 Regulating Histone Modifications in Chromatin 934.3 The & #8220 Histone Code& #8221 Hypothesis 954.4 Exploiting the Complexity of the Histone Code: & #8220 Crosstalk& #8221 Between Different Modifications 984.5 Are Histone Modifications Heritable Epigenetic Marks 1044.6 Conclusions 1065 Chromatin Remodeling and Nucleosome Positioning 111Gernot La& #168 ngst, Vladimir B. Teif, and Karsten Rippe5.1 Introduction 1115.2 Chromatin Remodeling Complexes 1125.3 Mechanisms of Nucleosome Translocations 1155.4 Positioning Nucleosomes in the Genome 1185.5 Gene Regulation via Nucleosome Positioning 1245.6 Conclusions 1276 The Folding of the Nucleosome Chain 139Karsten Rippe6.1 Introduction 1396.2 Experimental Systems 1406.3 Nucleosome& #8211 Nucleosome Interactions 1426.4 DNA Interactions with the Histone Octamer Protein Core 1456.5 Architectural Chromosomal Proteins and Chromatin States 1476.6 Chromatin Fiber Conformations 1506.7 Conclusions 1547 The Crowded Environment of the Genome 169Ron Hancock7.1 Introduction 1697.2 Basics 1697.3 Physicochemical Parameters of the Genome& #8217 s Environment 1717.4 Implications of a Crowded Environment for the Conformation of the Interphase Genome 1717.5 Assembly and Localization of Macromolecular Machines for Genome Transcription and Replication 1757.6 The Environment of the Genome during Mitosis 1777.7 Effects of a Crowded Environment on Searching for Targets in the Genome 1787.8 The Relative Importance of Entropic and Ionic Interactions for the Conformations and Interactions of Macromolecules in the Nucleus 1797.9 The Evolution of Genomes 1808 The Nuclear Lamina as a Chromatin Organizer 185Nikolaj Zuleger and Eric C. Schirmer8.1 Introduction 1858.2 Genome Organization with Respect to the Nuclear Periphery 1878.3 Interactions between NE Proteins and Chromatin Proteins/Chromatin Regulatory Proteins 1908.4 Mechanisms Directin and Quality Control 255Ute Schmidt and Edouard Bertrand11.1 Introduction 25511.2 Biosynthesis of Messenger RNA 25511.3 Nuclear Quality Control 26511.4 Cytoplasmic Messenger RNA Quality Control: Nonsense-Mediated Decay, No-Go and Non-Stop Decay 26811.5 Concluding Remarks 27312 The Nucleolus 279Saskia Hutten, Belinda J. Westman, Franc-ois-Michel Boisvert, Silvana van Koningsbruggen, and Angus I. Lamond12.1 Introduction 27912.2 The Nucleolus and Its DNA 28012.3 The Nucleolus and RNPs: Temporary Visitors or Permanent Residents 28512.4 The Nucleolar Proteome 29212.5 Concluding Remarks 29513 Non-Coding RNAs as Regulators of Transcription and Genome Organization 309Katalin Fejes To& #180 th and Gregory Hannon13.1 Introduction 30913.2 Classification of Non-Coding RNAs 31113.3 Small Regulatory RNAs and Their Diverse Nuclear Functions 31413.4 ncRNAs in Dosage Compensation 32413.5 Developmental Regulation of Hox Clusters by Cis- and Trans-Acting ncRNAs 32813.6 Mechanisms of Transcriptional Regulation by Long ncRNAs 33013.7 Conclusions 33814 RNA Networks as Digital Control Circuits of Nuclear Functions 353John S. Mattick14.1 Introduction 35314.2 The Information Content of the Genome 35314.3 The Hidden Layer of Developmentally Expressed Non-Coding RNAs 35414.4 RNA Control of Nuclear Functions 35514.5 RNA as the Adaptor in Digital& #8211 Analog Transactions 35614.6 RNA as the Substrate for Environment& #8211 Epigenome Interactions 35714.7 Conclusion 35815 DNA Replication and Inheritance of Epigenetic States 365Armelle Corpet and Genevie`ve Almouzni15.1 Replication in a Chromatin Context: Basic Issues and Principles 36515.2 Duplication of Nucleosome Organization 36815.3 Maintenance of Epigenetic Marks and Post-translational Modifications 37515.4 Concluding Remarks 38316 Interplay and Quality Control of DNA Damage Repair Mechanisms 395Berina Eppink, Jeroen Essers and Roland Kanaar16.1 Introduction 39516.2 DNA Repair Pathways 39616.3 Repairing DSBs 40016.4 Repair during Replication 40416.5 Interplay and Quality Control during DNA Damage Repair 40916.6 Applications of Mechanistic Insight in DNA Repair in Anti-Cancer Treatment 41017 Higher Order Chromatin Organization and Dynamics 417Hilmar Strickfaden, Thomas Cremer, and Karsten Rippe17.1 Introduction 41717.2 Higher Order Chromatin Organization: From 10-nm Thick Nucleosome Chains to Chromosome Territories 41817.3 Genome Accessibility 42417.4 Mobility of Chromosomal Loci and Nuclear Bodies 42617.5 Mitosis Causes Drastic Changes of Chromosome Territory Proximity Patterns in Cycling Cells 42917.6 Large-Scale Chromatin Dynamics in Nuclei of Cycling and Post-Mitotic Cells 43117.7 Considerations on Possible Mechanisms of Large-Scale Chromatin Dynamics 43418 The Mitotic Chromosome: Structure and Mechanics 449John F. Marko18.1 Introduction 44918.2 Structural Components of Mitotic Chromosomes 45018.3 Large-Scale Organization of Mitotic Chromosomes 45718.4 Mechanics of Mitotic Chromosomes 45918.5 Molecular Connectivity of Mitotic Chromosomes 46518.6 A Model for Mitotic Chromosome Structure and Function 46818.7 Open Questions 47419 Meiotic Chromosome Dynamics 487Nancy Kleckner, Liangran Zha Biowissenschaften Genetik Biophysics Life Sciences Biophysik Molecular Genetics Physik Chemie Chemische Biologie Genom Chemistry Biochemistry (Chemical Biology) Biochemie u. Chemische Biologie Cell Biology Molekulargenetik Physics Zellbiol, Wiley-VCH

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Genome Organization And Function In The Cell Nucleus - Wiley
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Genome Organization And Function In The Cell Nucleus - libro nuevo

2012

ISBN: 9783527640010

ID: 17117940

By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription. By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come. eBooks, , Genome Organization And Function In The Cell Nucleus~~EBook~~9783527640010~~Karsten Rippe, , Genome Organization And Function In The Cell Nucleus, , 9783527640010, Wiley, 01/09/2012, , , , Wiley

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Genome Organization And Function In The Cell Nucleus - Karsten Rippe
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Genome Organization And Function In The Cell Nucleus - libro nuevo

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InhaltsangabePreface xixList of Contributors xxi1 Deciphering DNA Sequence Information 1, Wiley-VCH

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Genome Organization And Function In The Cell Nucleus - Karsten Rippe
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Detalles del libro
Genome Organization And Function In The Cell Nucleus
Autor:

Rippe, Karsten

Título:

Genome Organization And Function In The Cell Nucleus

ISBN:

9783527640010

Detalles del libro - Genome Organization And Function In The Cell Nucleus


EAN (ISBN-13): 9783527640010
ISBN (ISBN-10): 3527640010
Año de publicación: 2012
Editorial: Wiley-VCH
400 Páginas
Idioma: eng/Englisch

Libro en la base de datos desde 05.02.2009 18:46:24
Libro encontrado por última vez el 09.06.2016 02:14:23
ISBN/EAN: 9783527640010

ISBN - modo de escritura alterno:
3-527-64001-0, 978-3-527-64001-0

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