Intracranial Germ Cell Tumors - Pasta blanda

EAN (ISBN-13): 9783709174142
ISBN (ISBN-10): 3709174147
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Tapa blanda
Año de publicación: 2011
Editorial: Springer Wien

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ISBN/EAN: 9783709174142

ISBN - escritura alterna:
3-7091-7414-7, 978-3-7091-7414-2
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Autor del libro: yutaka, tribolet
Título del libro: cell

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Datos del la editorial

Autor: Yutaka Sawamura
Título: Intracranial Germ Cell Tumors
Editorial: Springer; Springer Wien
369 Páginas
Año de publicación: 2011-09-22
Vienna
Impreso en
Idioma: Inglés
54,99 € (DE)

BC; Hardcover, Softcover / Medizin/Klinische Fächer; Neurochirurgie; Verstehen; Nervous System; Tumor; biopsy; carcinoma; cell; central nervous system; chemotherapy; classification; clinical trial; diagnosis; genetics; lymphocytes; pathology; radiology; radiotherapy; Radiaton Oncology; Neurosurgery; Oncology; Pediatrics; Radiology; Neurology; Pathology; Onkologie; Pädiatrie; Bildgebende Verfahren; Neurologie und klinische Neurophysiologie; Pathologie; BB; EA

I. Introduction.- II. WHO histological classification of tumors of the central nervous system (CNS): germ cell tumors (GCTs).- III. Epidemiology of CNS GCTs.- 1. Histological variation and incidence.- 2. Racial and geographical factors.- 3. Age factor.- 4. Gender factor.- 5. Anatomical factor.- 6. Genetic factor.- 7. Other factors.- IV. Pathology.- 1. General features of GCTs.- 2. Germinoma.- 3. Embryonal carcinoma.- 4. Yolk sac tumor (Endodermal sinus tumor).- 5. Choriocarcinoma.- 6. Teratomas.- V. Immunobiology of tumor infiltrating lymphocytes (TIL) in germinomas.- 1. Cell types of germinoma TIL.- 2. The cause and role of immune cell infiltration in germinomas.- 3. Cytotoxicity of TIL to tumor cells.- 4. Conclusive remarks.- VI. Genesis and genetics of intracranial germ cell tumors.- 1. Clonal evolution model for tumorigenesis.- 2. Oncogenes and tumor suppressor genes.- 3. Problematic of ontogenesis of CNS and extracranial GCTs.- 4. Oncogenesis of GCTs.- VII. Clinical findings and diagnosis.- 1. Neurological manifestations.- Radiological diagnosis.- 3. Endocrinological manifestations.- 4. Ophthalmological manifestations.- 5. Tumor markers.- VIII. Prognosis of CNS GCTs.- 1. Survival and recurrence after therapy.- 2. Outcome of patients.- IX. Overview of management.- 1. Classification of CNS GCTs for management.- 2. Diagnosis to select an appropriate treatment mode.- 3. Overview of treatment.- 4. Preliminary results of Japanese Cooperative Study.- X. Surgical management.- 1. Surgical strategy for germinomas.- 2. Surgical approaches to tumours of the pineal region.- Surgical anatomy.- Surgical techniques.- Complications.- 3. Stereotactic biopsy.- XI. Chemotherapy for CNS GCTs.- 1. Overall view of chemotherapy for CNS GCTs.- 2. Chemotherapy for recurrent CNS GCTs.- 3. Chemotherapy for newly-diagnosed CNS GCTs: neoadjuvant chemotherapy.- 4. Chemotherapy - only trials.- 5. Predictors of outcome to treatment.- 6. Myeloablative chemotherapy followed by autologous stem cell rescue for CNS GCTs.- 7. A view of the future.- XII. Radiotherapy for CNS GCTs.- 1. “Diagnostic radiotherapy” or radiation test.- 2. Radiotherapy for CNS germinoma.- 3. Irradiation volume and technique.- 4. Radiotherapy for CNS non-germinomatous GCTs.- 5. Stereotactic irradiation (STI).- 6. Future remarks.- XIII. Adverse effect of therapy and late sequelae in survivors.- 1. Effect of external radiotherapy.- 2. Induction of secondary tumors after irradiation.- 3. Hypothalamic-pituitary dysfunction and their management.- 4. Ototoxicity of chemotherapy.- 5. Clinical significance of pineal gland dysfunction.